Neutrophil dysfunction varies with the stage of canine visceral leishmaniosis
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چکیده
منابع مشابه
Neutrophil dysfunction varies with the stage of canine visceral leishmaniosis.
Canine visceral leishmaniosis (CVL) causes a dependent-stage alteration in neutrophil oxidative metabolism. When production of reactive oxygen species (ROS) exceeds the antioxidant capacity of neutrophils, apoptosis is triggered, impairing the viability and function of these cells, which can predispose dogs to infection. However, the uremic condition observed in late-stage CVL can also alter th...
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Visceral leishmaniosis was discovered in a male 12year-old Australian cattle dog in September 1994. Canine leishmaniosis has not previously been reported in Zambia. At necropsy, splenomegaly, fatty degeneration of the liver and focal lesions in the renal cortex were observed. Histopathologically, focal diffuse proliferation of amastigote-laden macrophages (ALM) were found in the spleen and live...
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ژورنال
عنوان ژورنال: Veterinary Parasitology
سال: 2013
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2013.02.016